High IgE may indicate allergies, immune system disorders, specific infections, etc. High lgE is an increase in serum immunoglobulin. lgE, also known as reactin, is a class of immunoglobulin in serum. increased total IgE in blood has the following significance. 1. allergy: due to allergic diseases, increased IgE is mainly seen in allergic body and allergic diseases, such as allergic asthma, allergic bronchitis, allergic rhinitis and other conditions will appear increased total IgE, and mast cell degranulation and histamine, bradykinin, leukotriene release is directly related to the release of the inflammatory mediators mentioned above are mediated by IgE. 2. Immune system disorders: the clinical symptoms mentioned above, such as dermatomyositis, dry syndrome, systemic lupus erythematosus, can also lead to an increase in total IgE. 3. Special infections: e.g. helminthic infections, idiopathic nephrotic syndrome can also cause high total IgE. It is recommended to consult a doctor in time to clarify the cause and take appropriate treatment measures.