Significant itching of the skin at the tailbone requires careful observation of the skin appearance of the itchy area. If the itchy area is keratosis-like hyperplasia, obviously raised on the skin, consider the possibility of neurodermatitis, the condition is related to poor rest and mental stress, there will be itching, scratching and itchy changes, it is recommended to choose to use tretinoin neomycin paste, with compound lactic acid cream and fluticasone propionate cream comprehensive treatment, which not only can make the keratosis of the skin gradually soften, but also can relieve Itching. If the itchy area of the skin shows obvious erythema, papules and blister-like changes, it is considered to be eczematous dermatitis, and it is recommended to choose to use zinc oxide cream or furnace glycolic lotion for treatment. If the itching is still not relieved, you can choose to take oral cetirizine hydrochloride tablets or desloratadine capsules.