Wasting is one of the adverse effects of metformin, which usually improves gradually when the dosage is adjusted or the medication is changed and the diet is adjusted according to the doctor’s instructions. The most common adverse effect of metformin is gastrointestinal reaction, which can cause vomiting, diarrhea, loss of appetite, abdominal pain and other symptoms, but also affects the absorption of nutrients, reduced intake and thus lead to weight loss. Therefore, it is recommended to take this product with or after meals to improve gastrointestinal reactions. However, if the symptoms are not relieved and there is persistent weight loss, consideration should be given to reducing the dosage. If gastrointestinal symptoms are not relieved after dosage reduction, or if blood glucose control is poor, it is recommended to follow the doctor’s instructions to change the medication, such as gliclazide. In addition to medication adjustments, a proper diet should be followed. Ensure the daily intake of total calories, protein, vitamins and other nutrients. Through diet and medication, wasting can be gradually relieved.