Lymphoblastic leukemia type B is usually treated with systemic chemotherapy, and other treatments include immunotherapy and hematopoietic stem cell transplantation. 1. Chemotherapy: choose suitable anti-cancer drugs to combine with chemotherapy, commonly used drugs include vincristine, adriamycin, methotrexate, azathioprine, etc. Specific chemotherapy program should be formulated according to the condition. 2. Immunotherapy: it is the treatment way to control and kill leukemia cells by stimulating and enhancing one’s own immune function, commonly used drugs such as rituximab, alemtuzumab, eptalizumab and so on. 3. Hematopoietic stem cell transplantation: it can be used as the second-line treatment for patients with high-risk or relapsed refractory leukemia. The treatment plan for lymphoblastic leukemia type B needs to be decided by the doctor according to the condition, and the above drugs should also be used under the doctor’s guidance.