The pain in the second and third toes may be caused by trauma, uncomfortable shoes, bunion, etc. Traumatic injuries may cause pain in the second and third toes. 1. Trauma: The pain in two toes and three toes is caused by injuries caused by external forces. Kicking and tripping may cause pain in normal life, and in more serious cases, fractures may occur. 2. Uncomfortable shoes: If you wear high-heeled shoes or tight shoes for a long time, it will lead to pain in the two toes and three toes when they are squeezed and rubbed by the upper part of the shoes, which will cause blood circulation obstruction and result in pain in the two toes and three toes. 3. Bunion: Bunion will squeeze the other toes, especially the second toe and third toe, which will trigger local inflammation and thus pain. It is recommended to go to the regular hospital for examination, the doctor will be based on clinical symptoms to give judgment, clear causes and timely symptomatic treatment.