TPOAb is thyroid peroxidase antibody and TGAb is thyroglobulin antibody, both of which are high enough to suggest that the patient may have thyroid disease. TPOAb is the hallmark antibody of autoimmune thyroid disease and is the gold standard for the diagnosis of Hashimoto’s thyroiditis, reflecting the presence of an autoimmune state of the thyroid gland but not the severity of the disease.TPOAb can also be detected in patients with Graves’ disease, patients with differentiated thyroid cancer, and patients with other mixed non-autoimmune thyroid diseases. TgAb positivity usually occurs in conjunction with TPOAb, suggesting that the causative agent of thyroid disease is autoimmune. The diagnosis of autoimmune thyroid disease is often made by testing for anti-TPO antibodies, which can be found in patients with Graves’ disease, non-toxic goiter, and thyroid cancer. In short, patients with two high indicators suggest that patients may have thyroid disease, it is recommended that patients according to the test results in a timely manner to the regular hospital for further examination, so as to avoid delay in the condition of the serious consequences.