There are different reasons for the pain of opening the mouth and cheeks, and the specific treatment measures are also different, mainly including myofasciitis, mumps, and mental factors. 1. Myofasciitis: patients with myofasciitis will experience pain when opening their mouths. They can take non-steroidal anti-inflammatory drugs such as acetaminophen under the guidance of a professional doctor, and if the pain is unbearable, they can take ibuprofen and other painkillers to alleviate it, and they can be supplemented with professional physical therapy such as massage. 2. Mumps: Because mumps is usually caused by viral infections, it is recommended that patients take antiviral drugs such as ribavirin. 3. Mental factors: For patients who have been in a state of stress for a long time, with high mental tension, it is easy for them to grind their teeth at night, which leads to excessive spasm of masticatory muscles and thus pain in opening the mouth. It is recommended that patients keep their moods happy and relax their minds, and seek the help of psychologists if necessary. There may also be other reasons, it is recommended to go to the hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or treatment. The application of drugs need to strictly follow the doctor’s instructions, if there is any discomfort can be discontinued to consult the doctor.