Although the prepared epiphyllum has gone through certain concocting procedures, it is still toxic and its long-term use will cause harm to the body, and should be used strictly under the guidance of a doctor. Epiphyllum is a more toxic Chinese medicine, and the concocted epiphyllums include salt epiphyllum, black shunpian, and white epiphyllum. Epiphyllum contains diester-type aconitine alkaloids such as aconitine, which is greatly reduced after concoction, and the corresponding toxicity is also greatly reduced. After hydrolysis of aconitine, the less toxic benzoyl aconitine is generated, with a toxicity of about one thousandth of the original, and after further hydrolysis, the toxicity is reduced to about one two thousandth of the original. After the concoction of the epiphyllum, although the toxicity is greatly reduced, but still has a toxicity. Oral administration of 0.2mg of aconitine can be poisoned, and its lethal dose is 3~4mg, and clinically, it can also produce toxic reactions such as nausea, vomiting, numbness of limbs and the whole body, diarrhea and so on. In the treatment with the preparation of epiphyllum, must pay attention to the dosage, and it is best not to take for a long time, so as to avoid toxic reactions.