Swelling of the lower extremity infection mainly with antibiotics, such as penicillin, cephalosporins, metronidazole, when the condition is more serious, you can also use the appropriate amount of glucocorticoids, but the specific drugs should be selected according to the specific circumstances of the patient. 1. Bacterial infections: the most common pathogens causing swelling of the lower limbs are bacteria, such as streptococcus, staphylococcus aureus, tetanus bacillus, etc. Different antibiotics can be used for different bacterial infections, and broad-spectrum penicillin, azithromycin and other treatments can be chosen before the pathogen is clearly identified. 2. Viral infections: swelling of lower limbs caused by viral infections is relatively rare, if it is clear that the viral infections can be treated with antiviral drugs, such as acyclovir, interferon, etc., and some symptomatic drugs can also be used. 3. Fungal infections: Swelling of the lower limbs caused by fungal infections is also more common, such as Candida albicans, pseudofilamentous yeasts, etc. Antifungal drugs such as fluconazole and itraconazole can be used. Overall, the principle of selecting drugs for lower extremity infections and swelling is to choose according to the pathogen, but infectious shock may occur when the lower extremity infection is serious, so it must be treated early to avoid the spread of infection. Drugs should all be used in accordance with medical advice.