It is not recommended to take drugs for rheumatic diseases during the acute period of upper gastrointestinal bleeding. Upper gastrointestinal bleeding, the first consideration may be and gastroesophageal fundus varices, gastric malignant tumors, acute gastritis and so on, it is recommended that the first treatment can be in the doctor’s guidance oral hemostatic drugs, such as Yunnan Baiyao capsule, omeprazole enteric-coated tablets and so on, mainly to play a role in stopping the bleeding and protection of the gastric mucosa. In the clinical treatment of rheumatic diseases, most of the choice of anti-inflammatory drugs and anti-rheumatic drugs, and anti-inflammatory drugs such as ibuprofen, diclofenac sodium, etc., the gastric mucosa has a certain degree of damage, so it is not recommended to take the above drugs orally during the acute period of upper gastrointestinal bleeding. It is recommended to wait until the gastrointestinal bleeding has completely stopped before taking oral treatment of rheumatic diseases. For patients with acute gastrointestinal bleeding, attention should be paid to monitoring the level of blood pressure and hemoglobin level, and when the level of hemoglobin is lower than 60 grams per liter, it is necessary to carry out blood transfusion and other treatments. When upper gastrointestinal hemorrhage occurs, it is recommended to consult the gastroenterology department of regular hospitals.