Want to go on the big and can not come out more than considered to be caused by constipation, but also may be rectal inflammation and stimulation and other factors caused by the symptoms of the RI. 1. Constipation: Lack of exercise, do not like to drink water, lack of dietary fiber in food and other lifestyle may cause constipation. At this time, you can apply some drugs to assist defecation, including Keserol, Mannitol, etc., to get the stool out. However, corkscrew and so on only serve to lubricate the stool in the final intestinal lumen, and their effect is rather limited. You can also use osmotic diuretics such as polyethylene glycol electrolyte bulk to assist in stool softening and promote defecation. 2. Inflammation of the rectum: If infection and other factors lead to inflammation of the rectal area, it will cause irritation of the intestinal tract, which makes the patient want to defecate, but because of inflammation stimulation rather than real feces caused by the stimulation of defecation, there will be a failure to come out of the situation at the same time. The patient should consult the gastroenterology department of the regular hospital, and if necessary, can improve the colonoscopy and other tests, but also at the same time with probiotics to regulate the intestinal flora. It is recommended that patients who want to go to the large size and can not come out, should consult the doctor in a timely manner, under the guidance of the doctor’s advice to take effective measures.