Toe skin keratinization, consider and callus, keratinized scaly tinea pedis, chronic eczema related. 1. Callus: often wear ill-fitting shoes, usually walk too much, resulting in local long-term friction or extrusion, may lead to skin keratinization. It is recommended to choose suitable, comfortable and breathable shoes and socks to reduce the adverse stimuli, and soak your feet in warm water every night, which can gradually improve with time. 2. Keratosis pilaris: Tinea pedis is caused by fungal infection, such as keratosis pilaris may lead to dry, flaky skin and obvious localized keratinization. Determine is caused by fungal infection, can give compound ketoconazole cream, bifonazole cream, ketotifen cream, oral itraconazole capsule, terbinafine hydrochloride tablets and other medications if necessary. 3. Chronic eczema: foot skin is stimulated by a variety of internal and external factors, resulting in eczema, especially chronic eczema, there will be skin thickening, keratinization, flaking, itching and other manifestations. At this time, you need to use hormone creams such as mometasone furoate, halometasone, etc., and if necessary, you can take oral antihistamines such as loratadine, cetirizine and other drugs. In summary, the factors that lead to keratosis pilaris are more, it is recommended to improve bad habits, reduce walking, avoid local friction, if necessary, to the hospital dermatology department for examination. If the disease is caused by, but also targeted to give medication. Drugs need to be used in accordance with medical advice.