ABO hemolytic jaundice usually refers to hemolysis of the newborn caused by ABO blood group incompatibility, which leads to pathological jaundice in the newborn. The pathogenesis of ABO hemolytic jaundice is usually caused by the incompatibility of the mother’s blood type and the fetus’ blood type. Usually, the mother’s blood type is O, and the fetus’ blood type is A or B is the most common. When ABO hemolytic jaundice occurs, the child’s skin and sclera will become jaundiced, and in severe cases, jaundice may also occur in the nerve cells of the brain nucleus. If the disease is not treated in a timely manner, it may result in more serious sequelae such as impaired mental development, hearing impairment or lifelong paralysis in the newborn. Blue light irradiation is generally preferred to reduce the symptoms of jaundice by lowering the serum unconjugated bilirubin, or by taking phenobarbital, an inducer of hepatic enzymes, or by intravenous gammaglobulin, etc., and if the conservative treatment is ineffective, then blood transfusion is needed. To sum up, ABO hemolytic jaundice is a kind of disease that can be recovered through treatment due to the occurrence of hemolytic reaction between the mother and the fetus with incompatible blood groups, thus causing jaundice symptoms.