Fructose increases blood uric acid levels and patients with high uric acid are advised to avoid fructose-rich sweetened soft drinks or fruit juices. Studies have confirmed the role of fructose consumption in hyperuricemia, i.e., patients consuming fructose-rich sweetened soft drinks or fruit juices may exhibit elevated blood uric acid levels and increased incidence of gout. The first step in fructose metabolism is the removal of a molecule of phosphate from ATP to produce ADP, which binds to fructose to form fructose-1-phosphate (phosphofructokinase), and then ADP is converted to AMP (adenylate kinase), which can be degraded to uric acid in multiple steps. Fructose is equivalent to a phosphate pool because the stripped phosphate can no longer combine with AMP and ADP to regenerate ATP. phosphate and ATP inhibit the uric acid degradation pathway (inhibiting AMP deaminase and 5-nucleotidase, respectively), and thus these compounds can promote uric acid formation as they are consumed. Patients with abnormal uric acid should visit the rheumatology and immunology department of the hospital in a timely manner, and standardize their treatment under the guidance of their doctors.