Colorectal melanosis has the potential to become cancerous. Colorectal melanosis is a non-inflammatory bowel disease characterized by melanin deposits in the mucous membrane of the large intestine, the essence of which is the presence of a large amount of lipofuscin material in the lamina propria of the colon. It often occurs in the cecum, transverse colon, descending colon, and sigmoid colon segments. Colorectal melioidosis disease is generally stable and can recover on its own over time if the causes and triggers are actively removed. Colorectal nevus may be associated with chronic constipation, poor dietary habits, poor medication history, etc. In some patients, it may also be due to repeated irritation such as intestinal inflammation. If intervention is not given in time and inflammatory factors persist, the risk of cancer may increase. Patients with colorectal neoplasia should go to regular hospitals in time to clarify the cause of the disease and take targeted treatment under the guidance of professional doctors.