Smelly feet and shoes may be related to poor hygiene, smelly sweat, athlete’s foot, diabetes, hyperthyroidism and other conditions, according to the cause of the disease, by paying attention to hygiene, medication and other methods of treatment, should be symptomatic treatment, there is no so-called “the best treatment”. 1. Poor hygiene: these patients need to pay attention to regular washing of shoes and socks, to avoid shoes and socks are not cleaned for a long time, bacteria and dirt in the shoes and socks accumulate, resulting in a noticeable odor. 2. Odorant sweating: odorant sweating needs to be treated by topical antiperspirant, such as 20% aluminum chloride anhydrous ethanol, which can reduce the secretion of sweat, and local botulinum toxin injection treatment if necessary. 3. Tinea pedis: patients with tinea pedis can be treated with antifungal medications such as ketoconazole ointment and miconazole nitrate ointment applied locally, and if the patient’s condition is more serious and difficult to control, it can also be combined with oral terbinafine hydrochloride tablets and other medications. 4. Diabetes: diabetic patients with diabetic foot, need to pay attention to diet control, while actively monitoring blood glucose, together with the injection of insulin medication, while paying attention to keep the foot skin clean. 5. Hyperthyroidism: For patients with hyperthyroidism and increased sweat secretion resulting in smelly feet, oral methimazole, propylthioxythiophene and other medications can be used to alleviate the symptoms. It is recommended that patients actively seek medical advice, strictly comply with the doctor’s instructions for the appropriate treatment, remember not to use drugs indiscriminately.