Dry skin next to the mouth, may be physiological factors (such as dehydration, etc.) or pathological factors (such as lipitis, lip allergies, etc.) caused by different causes of the different treatments, such as hydration, vitamin supplements, and so on. 1. Physiological factors If you are in a dry environment for a long time, change of seasons or don’t like to drink water, etc., it is recommended to drink more water, keep the humidity in the room suitable, and also apply vitamin E cream, silicon cream, etc. to keep the skin moisturized. 2. Pathological factors (1) Lip inflammation: mostly due to vitamin deficiency, bacterial infection, etc. For vitamin deficiency, it is recommended to take vitamin B or vitamin A. If it is caused by bacterial infection, it is recommended to apply antibiotics (such as erythromycin ointment) locally, and at the same time, take spectral antibiotics (e.g., cephalosporin, penicillin, etc.) orally. (2) Lip allergy: Mostly caused by lip contact with allergens. It is recommended to stay away from allergens, drink more water and adjust the diet, and with the topical anti-allergy drugs, such as glucocorticoid ointment. If the symptoms such as dry and flaky mouth are not relieved after using the medication, or accompanied by other symptoms, you should go to the hospital in time, and give targeted treatment after clarifying the cause.