Fatigue, lethargy, sleepiness, and lack of energy are often associated with oxygen supply to the brain and systemic metabolism. Tiredness, fatigue, sleepiness, and lack of energy are often seen in patients with cerebral atherosclerosis, most commonly in middle-aged and elderly patients with hypertension, hyperlipidemia, and hyperglycemia, which can lead to atherosclerosis in patients. Patients will show drowsiness, fatigue, dizziness, headache, fatigue, memory loss and so on. On top of the treatment, blood pressure, blood fat and blood sugar should be controlled. Flunarizine, Troxerutin and other vasodilator drugs can be applied. Patients with anemia may have fatigue, tiredness, sleepiness and lack of energy. If it is caused by anemia, the cause of anemia needs to be found. For example, iron deficiency anemia requires the patient to take iron supplements. In addition, hypothyroidism can also lead to fatigue, sleepiness and lack of energy, if this is the case, the patient needs to take thyroid hormone supplementation therapy. Tiredness, fatigue, drowsiness, and lack of energy suggest lifestyle adjustments, adequate sleep, and a balanced diet. If the symptoms continue to be unrelieved or aggravated, the patient should go to the hospital in time to clarify the cause of the disease and then carry out targeted treatment.