Oral mucosal disease can be identified under a doctor’s supervision, based on symptoms on the oral mucosa or through immunologic tests. Oral mucosal disease is usually a lesion of the oral mucosa as well as the soft tissues of the mouth caused by low immunity and other diseases of the body. Patients can be guided by their doctors to identify oral mucosal disease based on its presenting symptoms. Common symptoms usually include ulcers, abnormal keratinization, erosions, papules, nodules, atrophy, and desquamation on the oral mucosa. Oral mucosal disease can also be differentiated by immunological tests, fungal tests, exfoliative cytology, and blood tests under the supervision of a doctor to clarify the diagnosis. Oral mucosal disease can be identified under the guidance of a doctor to avoid self examination and misjudgment of the condition.