Generalized soreness and fever may be caused by physiological reasons, infectious diseases, malignant tumors or rheumatic immune diseases. 1. Physiological reasons: for example, climbing mountains, or because of work and other reasons overworked, there will also be generalized soreness and fever in the hands and feet. 2. Infectious diseases: bacteria, viruses and other pathogenic microorganisms infected, as an exogenous source of fever caused by the rise in body temperature, resulting in fever. The toxins of pathogens enter the bloodstream and stimulate the pain sensation to cause generalized soreness. 3. Malignant tumor: malignant tumor cells proliferate and invade normal tissues, consume a large amount of energy of the body, resulting in fatigue and pain. The metabolites and necrotic tissues of tumor act as endogenous thermogenic sources causing fever. 4. Rheumatic immune diseases: the immune system mistakenly treats its own tissues or cells as foreign objects for immune attack. As the immune response is also the process of inflammatory reaction, the secretion of inflammatory mediators and the absorption of immune complexes will cause fever, generalized pain and other symptoms. Generalized soreness hands and feet fever there are many other causes, the patient should go to the hospital in time, under the diagnosis of the doctor to determine the cause of the condition, according to different situations to take the appropriate treatment for treatment.