If patients with primary liver tumor have nausea and vomiting in the late stage, firstly, we should consider whether the nausea and vomiting are caused by the deterioration of liver function. If the patients have a sharp increase of ghrelin and ghrelin, and combined with bilirubin, this is mostly considered to be a kind of clinical manifestation caused by the deterioration of bilirubin and liver function. For this kind of situation, the patient’s poor liver function should be actively corrected, and some liver-protecting drugs should be injected intravenously, and plasma and albumin should be injected intravenously for supportive treatment if necessary. In addition, if the patient’s nausea and vomiting are more intense, it is necessary to carry out intravenous high nutritional therapy, that is, intravenous infusion of nutrient solution for further treatment. However, if the patient is due to tumor disease, which has metastasized to the gastrointestinal tract, and there is blockage or compression of the patient’s cardia as well as the gastrointestinal tract, it is recommended that the patient further search for the cause of the disease and check the patient’s obstruction site. If the obstruction is found, short-circuit surgery, i.e. fistula surgery, can be considered under laparoscopy or open abdomen if necessary, and jejunal nutrition tube can be placed for enteral nutritional elements treatment if necessary. Generally after the above treatment, the patient’s symptoms should be stabilized and can be maintained for a period of time.