Severe anemia with yellowish face may be caused by iron deficiency anemia, megaloblastic anemia, hereditary anemia and other reasons, which need to take medication, surgical treatment and general measures. 1. Drug treatment: for iron deficiency anemia, patients need to follow the doctor’s instructions to apply ferrous sulfate, iron dextrose and other iron agents. For megaloblastic anemia, patients should apply folic acid, calcium tetrahydrofolate, and vitamin B12 supplementation, etc. If the anemia is related to autoimmunity, glucocorticoid drugs such as dexamethasone, methylprednisolone, prednisone, etc., should be applied according to medical advice. If glucocorticoids cannot be used, immunosuppressive drugs such as cyclophosphamide, azathioprine, cyclosporine, or rituximab are prescribed. In severe cases, intravenous immunoglobulin is required. Secondly, for chronic blood loss, hemoglobin less than 60g/L and acute blood loss more than 30% of the total amount of blood, blood transfusion is needed. 2. Surgery: For patients with serious conditions, surgery should be considered, and common surgical methods include splenectomy and hematopoietic stem cell transplantation. 3. General measures: Some patients have folic acid deficiency, which should be supplemented by drugs or food. Patients need to pay more attention to rest and avoid strenuous exercise. To sum up, patients with severe anemia and yellowish face need to go to the hospital in time and actively cooperate with the doctor’s treatment. Drugs need to be used under the guidance of the doctor.