Methotrexate does not have the best time to take medication, you can choose the appropriate time to take medication according to the individual’s physical condition, the specific use of the advice to consult a doctor. If the individual has a normal gastrointestinal tract, there is no gastrointestinal disease, you can take methotrexate before meals, methotrexate before meals can be fully digested and absorbed, relatively speaking, the efficacy of the drug is better; if the individual usually have gastrointestinal diseases, if you take the drug before meals may cause gastrointestinal tract stimulation, resulting in discomfort, so you can usually choose to take it after meals. Methotrexate is a kind of widely used drug for class SLE, various types of acute leukemia, head and neck cancer, lung cancer, various soft tissue sarcomas, psoriasis, breast cancer, ovarian cancer, cervical cancer, malignant hyperemesis gravidarum, chorionic epithelial carcinoma, testicular cancer. Adverse reactions include gastrointestinal reactions, including stomatitis, mouth and lip ulcers, nausea, vomiting, abdominal pain, diarrhea; hepatic function impairment, including jaundice, alanine aminotransferase, alkaline phosphatase, gamma-glutamyltransferase and other increases; large doses of the application of hematuria, proteinuria, urinary oliguria, azotemia and even uremia; bone marrow suppression; and leukocyte low may be complicated by infection. It is forbidden to use in allergy, pregnant and lactating women. Note that there is a potential risk of secondary tumors, severe organ failure and infection should not be used. It is recommended to use medication under the guidance of a doctor, avoid self-medication.