Contraindications to estrogen supplementation include abnormal uterine bleeding, hormone-related tumors, and thrombophilia. 1. Abnormal uterine bleeding: estrogen can cause irregular vaginal bleeding, and estrogen may be related to the occurrence of endometrial cancer, when there is unexplained abnormal uterine bleeding, estrogen is prohibited. 2. Hormone-related tumors: those who suffer from breast cancer or suspected of breast cancer are prohibited to supplement estrogen and progestin. Supplementation of estrogen and progesterone is prohibited for other estrogen and progesterone sensitive cancer patients. Patients with uterine fibroids and other patients should use estrogen-related drugs with caution. 3. Thrombotic diseases: estrogen can make coagulation factors rise, large doses of estrogen can cause thrombotic diseases. Deep vein thrombosis, pulmonary embolism, thrombotic heart valve disease, etc., supplementation of estrogen is prohibited. Supplementation of estrogen and progesterone should be used under the guidance of a professional doctor, and should not be used privately, so as not to cause discomfort.