Anti-skin keratinizing medications generally include retinoic acid cream, urea ointment, salicylic acid ointment, and so on. When the phenomenon of hyperkeratosis occurs, it is recommended to choose the right medicine under the guidance of the doctor. 1. Vitamin A acid ointment: For patients with blackheads, acne or chicken skin on the face, you can use vitamin A acid ointment, which can promote epidermal cell renewal, regulate the proliferation and differentiation of epidermal cells, and make the stratum corneum cells loose and easy to fall off, so that it has an antikeratinizing effect, thus unclogging the blocked pores. 2. Urea ointment: the principle of urea ointment anti-keratinization is to promote the dissolution of keratin denaturation, clinically applicable to keratinized tinea versicolor and chapped hands and feet. 3. Salicylic acid ointment: 5%-10% salicylic acid has a dissolving effect on keratin, and at the same time has an antifungal effect, can also be used for keratinized tinea pedis. When the phenomenon of hyperkeratosis of the skin, it is recommended to go to the regular hospital in time for examination and symptomatic treatment under the guidance of professional doctors.