Large teeth, also known as grinders, grinders neuralgia may be pulpitis or periapical neuritis, trigeminal neuralgia, cardiogenic pain, depending on the situation need root canal treatment or medication, surgical treatment. 1. Pulpitis or apical periodontitis. Treatment usually requires root canal therapy, which removes the infected pulp and then fills the root canal, relieving pain. 2. Trigeminal neuralgia. Pain in the third branch of the second branch of the trigeminal nerve can also cause pain in the tooth, which is cut-like and often lasts for several seconds. Treatment can use carbamazepine or acupuncture, physical therapy, severe cases need to be treated with surgery. 3. Pain of cardiac origin. Angina and other cardiac systemic diseases can also cause toothache, and the pain can be radiated to the ear temporal and dorsal parts, can be sublingual nitroglycerin or take surgical treatment. Tooth nerve pain need to check the cause of pain, targeted treatment, medication need to follow the doctor’s instructions.