Body itching in liver cancer patients after surgery may be caused by incomplete metabolism of bilirubin, drug factors, allergy and so on. Liver cancer is a common malignant tumor of digestive system, which can be caused by hepatitis virus, alcohol and other factors. The main treatment after diagnosis is surgical resection. 1. some liver cancer patients have jaundice symptoms, which can be manifested as yellowing of skin and sclera, itching of skin, etc. If bilirubin has not been metabolized after surgery, itching of skin may occur; 2. some hepatocellular carcinoma patients need to receive adjuvant therapy after surgery, such as targeted therapy, chemotherapy, etc., and may have adverse reactions such as skin itching. Such as Sorafenib with skin and subcutaneous tissue diseases (rash, erythema, itching, etc.); 3. allergic reactions or skin diseases. In addition to the drug and the disease itself can cause itching, dermatologic diseases (neurodermatitis, etc.), food, drugs, mosquito bites, pollen allergies and so on. If any of the above abnormal manifestations occur, it is recommended to go to a regular hospital to assess the condition and follow the doctor’s instructions to cooperate with the treatment, so as not to delay the condition.