Difference between alanine aminotransferase and glutamine aminotransferase is source, reference range, and clinical significance.
1.Source:Glutamine aminotransferase it is most abundant in the liver, followed by the kidneys. In the liver it is mainly found in the cell cytoplasm. Glutamine aminotransferase it is mainly found in the myocardium, liver, and brain tissue at the highest level, followed by skeletal muscle and kidney. In the liver, it is mainly found in the mitochondria of hepatocytes.
2. Reference value range: Reference value of AST 5-25(karmen method) U; Reference value of AST 8-28(karmen method) U.
3. Clinical significance: Both are present in normal hepatocytes and are the most sensitive test for liver damage. Minor hepatocellular inflammation can double the serum enzyme activity, thus reflecting to some extent the degree and amount of hepatocellular damage. Since the activity of AST is highest in the liver, the AST assay is more specific for the liver than the AST.
In case of abnormal liver function test results, it is recommended to seek prompt medical attention to identify the cause of the disease with the help of a doctor, and to carry out targeted management or treatment.