Itchy blisters on the feet may be a symptom of tinea pedis, pemphigus, papular urticaria, or impetigo, and require antiallergic, antifungal, or antibacterial treatment for different causes. 1. Tinea pedis occurs on the cracks of the toes and the soles of the feet, manifesting as blisters, flaking and itching of the skin on the feet. It can be treated with topical fungicidal creams such as terbinafine hydrochloride cream and ketoconazole cream, combined with oral antifungal drugs such as itraconazole. 2. Sweat herpes is a special type of eczema, manifesting as thick blisters on the soles of both feet symmetrically, with intense itching. It can be treated with topical glucocorticoid drugs such as mometasone furoate cream and halometasone cream. Topical urea cream can relieve the symptoms of peeling skin in the later stage. 3. Papular urticaria is caused by insect bites, manifesting as scattered red bumps on the feet, small blisters on the surface of the bumps, and obvious itching. It can be treated with anemone, salbutamol cream, glycerite lotion and so on. 4. Impetigo is caused by bacterial infection, and autoimmune low related, mostly appear in the feet after skin injury. It can be treated with topical fusidic acid cream, mupirocin ointment, etc. In severe cases, antibiotics such as penicillin can be used. It is recommended that patients with blisters on their feet consult a doctor in a timely manner and follow the doctor’s instructions for treatment.