Available drugs: Oral first-line antituberculosis drugs include isoniazid, rifampin, pyrazinamide, and ethambutol. Patients with multidrug-resistant tuberculosis have developed resistance to at least isoniazid and rifampin, so pyrazinamide and ethambutol can be chosen, but it cannot be excluded that the patient is already drug-resistant. Xepeng Bai, Department of Thoracic Surgery, Shandong Chest Hospital Injectable drugs include streptomycin, kanamycin, amikacin (also known as butamycin), and capreomycin. Since all of these drugs can produce adverse effects such as hearing loss, renal function and vestibular dysfunction, only one of these drugs can be used. The order of choice should be streptomycin, kanamycin or butamycin. Those who are resistant to the first 3 drugs can use curlywheat. Fluoroquinolones include ofloxacin, levofloxacin, moxifloxacin, and gatifloxacin. Among them, the highest bactericidal activity is moxifloxacin, followed by levofloxacin and ofloxacin. Oral second-line antibacterial agents include pro(ethyl)sulfisonicotinamide, p-aminosalicylic acid and cycloserine. Drugs whose efficacy has not yet been confirmed Such as chlorpheniramine, hydroxybenzyl penicillin-rod acid combination, and linezolid. Treatment of multidrug-resistant tuberculosis is not only difficult (even more so for severe multidrug-resistant tuberculosis), but also the drugs are more expensive or can produce a variety of adverse effects such as liver and kidney function impairment and gastrointestinal discomfort, and their efficacy is far less than that of initial treatment of tuberculosis and initial retreatment of tuberculosis. Even according to the 24-month long treatment course program recommended by the World Health Organization, the efficacy is only about 70%. Treatment principles: ★Establish a treatment plan. Based on the results of drug sensitivity tests, at least 4-5 sensitive drugs are selected for inclusion in the long course of treatment. This includes an intensive period of 6 months and a continuous period of 18 months. For those who are still sputum positive, the intensive period should be extended until the sputum is negative. A new treatment regimen may be established based on previous treatment history and the results of drug resistance surveillance surveys in the area until drug sensitivity test results are available. ★ Early detection and treatment. Adhere to the principles of combination, regularity, adequate dosage and whole course. Adhere to daily or 6 times a week dosing. ★ Conduct the whole course of supervised treatment under direct face-to-face observation. So as to make patients adhere to treatment and timely detection and management of adverse reactions. ★ Review sputum TB bacteria regularly. Including sputum smear and sputum culture. In combination with clinical manifestations and chest X-ray changes, timely adjustment of treatment plan. ★Supplement with immunotherapy, surgical treatment and interventional therapy when necessary.