Melanin on both sides of the thighs need to identify the cause to remove, may be physiological, may be pathologic; both need to be under the guidance of the doctor to carry out targeted treatment, such as medication, surgical treatment, etc.. 1. physiological: inner thigh melanin precipitation is mainly considered to be due to the usual friction caused by more, you can try to apply hydroquinone cream in the local melaninization of the treatment, if necessary, patients can also consider going to the regular hospital for laser removal. 2. Pathological: For example, when ringworm develops on the inner thighs, it is often seen as red patches in the affected area, accompanied by flaking, with burning or itching sensation, due to constant scratching or recurrent episodes, infiltration and thickening of the femoral skin occurs and is called mossy, similar to the melanosis-like skin lesions. It can be treated with topical application of antifungal drugs such as sertaconazole nitrate, amorolfine cream, etc. Generally, after the disease is cured, the melanosis will also subside. For patients who need to remove melanin on both sides of the thighs, they should consult a doctor in a timely manner to clarify the cause and then give targeted treatment, do not blindly self-medication.