Varicose veins are generally characterized by twisting, dilatation and lengthening of the larger superficial vein trunks and their branches in the lower extremities. Patients with varicose veins of the lower extremities often have a combination of nocturnal cramping pain, which becomes more frequent as the condition worsens, but the exact cause is unknown. Leg cramps in patients with varicose veins should not be related to low calcium, but may be related to stagnant blood flow in the veins, where metabolic waste products in the stagnant venous blood irritate the nerves, leading to muscle spasms, which can be relieved by Myzolene or Avellan.