Hypothyroidism face edema after iodine 131 is usually recoverable after medication and dietary regimen. The destruction of thyroid tissue after iodine 131 causes a decrease in thyroid hormone secretion, which leads to hypothyroidism. The skin is keratinized, there is mucous edema in the dermis, and the intercellular fluid accumulates large amounts of hyaluronic acid, mucopolysaccharides, chondroitin sulfate, and water, resulting in non-indented edema. After the diagnosis of hypothyroidism, it is necessary to follow the doctor’s instructions for long-term use of levothyroxine sodium tablets as a replacement therapy to restore the body’s metabolism, so that the mucopolysaccharide material is gradually metabolized, and the edema will slowly disappear. With the prolongation of the treatment time, the thyroid function gradually returned to normal, facial edema can be restored. Dietary advice is to eat a low-salt, low-fat diet, pay attention to balanced nutrition, and eat more fresh vegetables and fruits. If you feel unwell during the treatment, consult a doctor promptly.