Itching of the vaginal opening in women may be caused by urinary tract infection, because the vaginal opening and the urethra are very close to each other, and urinary tract infection can cause itching of the vaginal opening. It is recommended that the patient go to the hospital for routine urine examination in time. If it is clear that it is a urinary tract infection, it is recommended to apply levofloxacin capsules to control the inflammation in time, which can effectively improve the itching situation. In addition, it may also be due to improper hygienic treatment of the patient’s perineum, which can also cause itching at the vaginal orifice and urethra due to pollutant contamination, and timely washing can effectively improve the itching symptoms. Itchiness can also be caused by inflammation in the vagina. The vaginal discharge should be examined in time to clarify the diagnosis, and then the infection can be controlled by taking levofloxacin capsules to improve the itchiness.