Selegiline normal dose is usually taken without significant damage to the kidneys, renal insufficiency need to follow the doctor’s advice according to the condition of the drug. This product for diabetic patients, can improve the body’s insulin function, stimulate the pancreatic islet cells secretion of insulin, used for type 2 diabetes mellitus patients with blood glucose control, can be used in combination with metformin hydrochloride, but also used to improve the poor glycemic control of type 2 diabetes mellitus after a sulfonylurea single-agent treatment. Generally, normal dosage has no damage to the kidneys, and patients with renal insufficiency need to adjust the dosage of the drug according to the doctor’s instructions. Adverse reactions commonly include abdominal pain, diarrhea, nausea, and rarely pancreatitis, elevated liver enzymes, arthralgia, etc. If there is a generalized itchy rash, swelling of the lips, face, or throat, a severe allergic reaction may have occurred, and the medication should be discontinued and the patient should go to the hospital immediately. Moderate to severe renal insufficiency should be used with caution, type 1 diabetes mellitus or diabetic ketoacidosis patients are prohibited, pregnant and lactating women are not recommended to use. If diagnosed with diabetes, it is recommended to consult a regular hospital, complete the relevant examinations, the doctor to develop treatment methods, strictly comply with the doctor’s instructions to use medication, and control the diet and proper exercise, do not blindly self-medication, so as not to delay the condition or cause adverse reactions.