Antibiotic resistance may persist after a period of time off the antibiotic. For some pathogens the resistance will continue, and the development of resistance does not restore the drug’s sensitivity to the pathogen. Some pathogens that are resistant to antibiotics will regain their susceptibility after a period of time off the antibiotic. It is best to do a bacterial culture with antibiotics, choose effective antibiotics for treatment, choose a sufficient amount of antibiotics, pay attention to the adverse effects of antibiotics, precautions and contraindications, antibiotics are prohibited for people who are allergic to antibiotics, allergic to people use antibiotics with caution, antibiotics may harm the liver and kidneys, and some cause rashes, itching, dizziness, headache and other adverse reactions. After stopping for a period of time with antibiotic resistance, if you want to use antibiotics again, you need to use antibiotics under the guidance of a physician’s visit in accordance with the specifications to avoid the re-emergence of drug resistance, the patient should not use the drug on their own.