Pregnant women over 40 years of age should pay attention to regular obstetric checkups, folic acid supplementation and maintaining a healthy lifestyle during the early stage of pregnancy. 1. Regular obstetric examination: pregnant women over 40 years old may have more abnormalities after pregnancy. Pregnant women should have regular obstetric examination according to the schedule of obstetric examination and dynamically observe the indicators. In the early stage of pregnancy, the value of HCG should be paid attention to, so as to avoid miscarriage, fetal arrest and so on. Must do a good job of Down’s syndrome screening and four-dimensional ultrasound examination. 2. Supplement folic acid: the probability of neonatal malformation increases after pregnancy in elderly pregnant women over 40 years old, pregnant women should do a good job of folic acid supplementation, and don’t forget to take one folic acid tablet a day in the first 3 months of pregnancy. 3. Maintain a healthy lifestyle: Diet after pregnancy should be light and nutritious, food should be varied to ensure the growth and development of the fetus. Pay attention to rest, don’t be tired, stay up late, don’t smoke, prohibit drinking alcohol, and keep a good mood.