There are many reasons for penis burning and itching, which can be categorized into physiological and pathological reasons, and pathological reasons include urinary system diseases, reproductive system diseases and skin diseases. 1. Physiological: If men wear thicker underwear or too tight jeans in summer, or sweat more after a lot of exercise, this symptom may occur. These are normal physiological phenomena and do not require special treatment. 2. Pathological: If you suffer from urinary system diseases, such as urethritis and cystitis, because the urethra is located in the penis, so the inflammation of this part will lead to the above symptoms; there are also diseases of the reproductive system, such as glans, etc., which will produce this symptom due to inflammation; as well as neurodermatitis and eczema and other skin diseases, which can also produce this symptom. If you suspect that the symptoms are pathologic, it is recommended that you seek medical attention in a timely manner.