The causes of many small honeycomb holes on the soles of the feet include fossa keratosis, plantar warts, tinea pedis, eczema, etc. The treatment includes medication. 1. Keratosis Pilaris: It may be a skin disease caused by corneal erosion in the metatarsal area of the genus Corynebacterium, which can be treated with erythromycin cream. 2. Metatarsal warts: For small holes in the honeycomb caused by metatarsal warts, freezing and laser treatment are used. 3. Tinea pedis: If you have a lot of honeycomb holes on the soles of your feet caused by a fungal infection, you can give bifonazole, isoconazole and other drugs for antifungal treatment. 4. Eczema: If eczema is the cause of cellular holes, you can give hydrocortisone, budesonide and other drugs anti-inflammatory treatment. Finally, the appearance of the soles of the feet have a lot of cellular holes phenomenon, please consult a doctor in a timely manner to clarify the cause of the disease, the use of all drugs need to follow the doctor’s instructions.