The edge of the panties at the base of the thighs of women include the perineum and groin, if there are lumps and pain in these areas, it should be considered related to inguinal hernia, enlarged lymph nodes, vestibular gland cysts or abscesses. 1. Inguinal hernia: this disease is due to congenital or acquired defects caused by the weakness of the abdominal wall, in coughing, defecation and other abdominal pressure increases will appear local small lumps, if the local protruding tissues of the incarceration will lead to the local combination of pain and other discomforts. 2. Enlarged lymph nodes: if the patient has urinary tract infection or pelvic inflammatory disease, because the inflammation can spread to the nearby lymph nodes, the enlarged lymph nodes with pain can be touched locally; if the patient has malignant tumor such as cervical cancer, the enlarged lymph nodes can be touched when the cancer cells spread to the lymph nodes of inguinal area. 3. Vestibular gland cyst or abscess: if the duct of vestibular gland is blocked, it will lead to the glandular fluid cannot be discharged normally, and then it will stagnate in the local area and form a retention cyst, which can be touched locally as a lump, and if there is a combination of bacterial infection, it will cause obvious pain. For women with painful lumps on the edge of their underwear at the base of their thighs, it is recommended that they go to the gynecology department of a regular hospital, complete ultrasound, blood tests and other relevant examinations, and then take active treatment under the guidance of the doctor after clarifying the cause of the disease.