It is usually okay to take metoprolol and propafenone together, but it should be taken under doctor’s supervision. Metoprolol belongs to a kind of beta-adrenergic receptor blocking drug, which is commonly used in the clinical treatment of hypertension, angina pectoris, myocardial infarction and other diseases. Propafenone is an antiarrhythmic drug, commonly used in the treatment of paroxysmal ventricular tachycardia and supraventricular tachycardia. Usually the two drugs can be taken together without inducing abnormalities, but they need to be strictly administered under the supervision of a doctor. Metoprolol is contraindicated in cases of cardiogenic shock, sick sinus node syndrome, atrioventricular block of the third degree, hypersensitivity to the components of the drug. And the main contraindications to propafenone are severe atrioventricular block, severe congestive heart failure, cardiogenic shock, severe hypotension, sinus node dysfunction without pacemaker protection are contraindicated. It is recommended that patients take Metoprolol and Propafenone as prescribed by the doctor, and should not use the medication on their own or increase or decrease the dosage during the medication. If the medication is accompanied by uncomfortable symptoms, the medication should be discontinued and medical treatment should be sought.