The main difference between skin bilirubin measurement and blood bilirubin measurement is that the former is convenient and non-invasive, instrument operated, but may be missed and misdiagnosed, while the latter is invasive and more credible in diagnosis. 1. Transcutaneous bilirubin instrument: Transcutaneous bilirubin measurement is a non-invasive, simple to operate method of measuring bilirubin. It has high sensitivity and specificity, and is an effective test for clinical diagnosis of hyperbilirubinemia and neonatal jaundice. However, it has a certain leakage rate and misdiagnosis rate, and can only be used as a useful tool for home monitoring and early screening. 2. Serum total plasma bilirubin measurement: Serum total plasma bilirubin measurement is the gold standard for assessing bilirubin levels, but it is an invasive procedure that requires specialized medical personnel to collect blood and test. However, invasive blood sampling can lead to an increased risk of infection. Although they have their own advantages and disadvantages, they are well correlated and can be used in combination to diagnose related diseases. If you need to use percutaneous bilirubin measuring equipment or serum total plasma bilirubin measurement, you should go to the hospital in time and actively cooperate with the doctor’s treatment plan, do not do it by yourself.