Perimenopause is the medical term for menopause. Perimenopausal symptoms such as hot flashes and hot hands generally belong to perimenopausal syndrome, which can be treated with estrogen or progesterone as prescribed by the doctor. Perimenopausal syndrome refers to a series of physical and mental symptoms caused by fluctuations or decreases in sex hormones before and after menopause, which may manifest as hot flashes, excessive sweating, anxiety, irritability, insomnia and so on. At this time, estrogen can be taken, such as natural oral estrogen (such as conjugated estrogen, estradiol valerate, nil estradiol tablets, etc.) and transdermal absorption of estrogen (such as estradiol skin patch, estradiol gel, etc.). Progestogens can also be taken, such as medroxyprogesterone acetate and micronized progesterone. Perimenopausal symptoms of anger and hot hands, it is recommended to consult a doctor in a timely manner, improve the relevant examination, under the guidance of a professional doctor to clarify the cause of the disease, and symptomatic treatment. The above drugs should be used under the guidance of a doctor, do not blindly take on their own.