The heart rate of fifty times per minute is not normal after taking Bisoprolol, which is an adverse drug reaction. Usually the normal range of heart rate of normal adults is 60~100 beats per minute, heart rate of fifty times per minute, electrocardiogram will suggest sinus bradycardia. If the above symptoms occur after taking Bisoprolol, it is an abnormal situation, which may be caused by the adverse reaction of the drug, if you feel sick, you should seek medical advice. Bisoprolol belongs to the category of beta receptor antagonists and is mainly used to treat hypertension, coronary heart disease, heart failure and other diseases. Note that the use of this drug can affect the cardiovascular system, resulting in bradycardia, atrioventricular conduction disorders and other discomforts. Bisoprolol is contraindicated for people with acute heart failure and cardiogenic shock; pregnant women, lactating women and other special groups, need to use the drug under the guidance of a doctor. If there is any discomfort in the process of taking the medicine, it is recommended to consult a doctor in a timely manner, and all clinical medications should be used under the guidance of a doctor, to avoid self-medication, so as to avoid adverse consequences.