Valsartan hydrochlorothiazide and valsartan amlodipine have different compositions, scope of application, and adverse reactions. 1. Different composition: the main component of valsartan hydrochlorothiazide is valsartan hydrochlorothiazide, which has diuretic effect while lowering blood pressure, and valsartan amlodipine is composed of valsartan and amlodipine, which is capable of lowering blood pressure and expanding coronary arteries at the same time. 2. Scope of application: valsartan hydrochlorothiazide is suitable for patients with hypertension accompanied by cardiac insufficiency and edema, and valsartan amlodipine is more suitable for patients with hypertension accompanied by coronary artery disease. 3. Adverse reactions: valsartan hydrochlorothiazide has a diuretic effect, which can lead to electrolyte disorders, and patients with valsartan amlodipine can have lower limb edema, constipation, tachycardia and so on. Most patients can be treated with oral valsartan hydrochlorothiazide and valsartan amlodipine, but the drugs have their own advantages, and it is important to choose the right drug for the patient under the guidance of the physician.