Itopride and Mosapride belong to the same category of pro-gastrointestinal dynamics drugs, each person’s basic physical condition, contraindications and tolerance to drugs are different, should be depending on the condition of the choice of suitable drugs. Itopride is a dopamine D2 receptor antagonist and cholinesterase inhibitor. It can enhance the contractility of the stomach and duodenum, accelerate gastric emptying, and inhibit the effect of vomiting. It is mainly used for the treatment of dyspeptic symptoms caused by weakened gastrointestinal power, such as nausea, vomiting, abdominal distension, abdominal pain, loss of appetite, etc. Adverse reactions such as abdominal pain, diarrhea, leukopenia, allergy, etc., may occur during administration. It is contraindicated in patients with gastrointestinal bleeding, intestinal obstruction or gastrointestinal perforation. Mosapride belongs to the 5-HT4 receptor agonist, which can promote, the release of acetylcholine in the intestinal interosseous plexus, enhance gastrointestinal power. It is mainly used for functional dyspepsia with heartburn, belching, early satiety, epigastric distension and other digestive symptoms. Common adverse reactions are diarrhea, dry mouth, fatigue, liver dysfunction, etc. It is contraindicated in patients who are allergic to the product. The choice of drugs is the doctor in weighing the pros and cons of the individualized treatment plan, patients do not need to be too obsessed with which drug is more effective, follow the doctor’s instructions to take the most suitable for their own medication, to avoid adverse effects.