Hepatocellular carcinoma of moderate to low differentiation is usually not more serious after resection, and at present, the main treatment for hepatocellular carcinoma is still based on surgery. Intermediate and low differentiated hepatocellular carcinoma refers to the higher degree of malignancy and poorer prognosis, while the current treatments for hepatocellular carcinoma include surgery, interventional therapy, radiotherapy and targeted drug therapy. For those who can undergo surgical resection, the most important thing is to take surgical resection. For middle and low differentiated hepatocellular carcinoma, after surgery, according to the staging, it can be treated with radiotherapy and other methods, which can further kill the residual cancer cells and prevent further recurrence of cancer cells, but surgical resection will not make the condition more serious. When hepatocellular carcinoma occurs, one should actively consult the doctor and follow the doctor’s prescription for reasonable treatment.