Penis long blisters may be related to genital herpes, skin allergies, condyloma acuminatum, glans, syphilis and other conditions, need to be symptomatic medication, genital herpes can be used for acyclovir, etc., allergies can be used for loratadine, etc., condyloma acuminatum can be used for imiquimod cream, etc., glans can be used for clotrimazole cream, etc., syphilis can be used for procaine penicillin and so on. 1. genital herpes: is infected with herpes simplex virus, in the penis or glans area, there will be a gathering presence or scattered blisters, there is obvious pain. Antiviral drugs such as oral vasiclovir and acyclovir can be taken, and acyclovir cream can be applied locally. 2. Skin allergy: If the penis comes into contact with allergy-prone substances, it may cause itching and blisters. Take cetirizine hydrochloride and loratadine orally to treat allergic symptoms. 3. Condyloma acuminatum: This is caused by infection with the HPV virus, and will appear as cockles or cauliflower-like bumps with obvious pain. It can be treated by applying imiquimod cream and interferon gel. 4. Glansitis: it is caused by inflammation stimulation, patients can apply miconazole cream, clotrimazole ointment treatment. 5. Syphilis: this is due to syphilis spirochete infection, a few patients will appear blisters. Procaine penicillin and other drugs can be used to treat. It is recommended that patients seek medical attention in a timely manner to clarify the cause of the disease, and then strictly comply with the doctor’s instructions to use medication. If the effect of drug treatment is not good, it can also be handled with other methods.