Lupus erythematosus body pain may be due to the disease invades the skin, joints, tissues and organs, resulting in muscle and joint swelling and pain, headache, chest pain and other symptoms. Lupus erythematosus is a type of connective tissue disease with a complex etiology and uncertain pathogenesis. It is classified as systemic lupus erythematosus and cutaneous lupus erythematosus. Due to the abnormalities of the immune system, the disease may involve multiple organs and systems, and lead to skin lesions, headaches, chest pain, muscle pain, and other symptoms, and the patient may experience pain all over the body. Depending on the type of lupus and the patient’s specific condition, lupus patients with body pain can be treated with non-steroidal anti-inflammatory drugs (NSAIDs) such as celecoxib, glucocorticosteroids such as prednisone acetate tablets, immunosuppressants such as cyclophosphamide, etc., as prescribed by the doctor, and the patient’s condition can be relieved and disease progression can be controlled through active treatment. It is recommended that patients with lupus erythematosus with symptoms such as body aches go to the rheumatology and immunology department of regular hospitals for active treatment.