The skin long closed mouth is considered to be closed mouth pimples, which is a type of acne and can be treated with topical benzoyl peroxide gel, retinoic acid ointment and other medications. 1. Benzoyl peroxide gel: as a keratolytic agent, through the release of active oxygen, kill Propionibacterium acnes and make the skin dry and flaky, clinically mainly used for common acne. Adverse reactions may cause burning sensation, itching, redness, swelling, dryness and flaking of the skin. Acute inflammation of the skin, as well as those with ulceration are prohibited from use. 2. Vitamin A Acid Ointment: It can eliminate acne lesions by regulating the abnormal process of epithelial keratinization of the sebaceous glands of the hair follicles and removing the keratin plugs. Clinically, it is mainly used for acne vulgaris, hyperpigmentation skin disease, psoriasis and so on. Adverse reactions may cause skin irritation such as burning sensation, skin erythema, and flaking. It is contraindicated in women during the first trimester of pregnancy and in patients with acute and subacute dermatitis and eczema-type skin. It is recommended to go to the hospital for examination first, to clarify the cause of the disease, follow the doctor’s instructions to use the drug, to avoid their own abuse of drugs.